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Bioactive components and functional foods for health promotion
Monday, 13 July, 2020, 08 : 00 AM [IST]
Katke S D, Deshpande H W, Sawate A R
Today, consumer’s demand for food is gradually shifting from price, taste and convenience to health and wellness due to more awareness towards health. The idea of health promoting foods is however not new.  Hippocrates wrote 2400 years ago “Let food be thy medicine and medicine be thy food”.

These days, healthy foods refer to functional foods that have positive effect on particular body functions, beyond the traditional nutritional effects. The ideal functional foods are the ones that are carrying bioactive components such as oligosaccharides, phytochemicals, dietary fibre, and active friendly bacteria or probiotics and include products like baked goods and cereals, baby foods, ready meals, snacks, dairy foods, confectionery, meat products, spreads, and beverages.

The term “functional foods” was introduced by the Japanese government in the mid-1980s and functional food concept obtained the legal status in 1991 by setting up “Foods for Specified Health Use” (FOSHU) regulatory system. Functional foods like conventional foods are eaten as a part of the normal diet but have additional physiological benefits. They can minimise the risk of chronic disease and maintain gut health because functional food supplies the human body with essential amount of fats, vitamins, proteins and carbohydrates, required for its healthy survival.

Functional foods are the food products which provide numerous health benefits on consumption beyond the traditional nutrients because of several bioactive components present in them. Several bioactive components in food include ?-3 and ?-6 polyunsaturated fatty acids (mainly conjugated linoleic acid and docosahexaenoic acid), polyphenols, probiotics/prebiotics, phytoestrogens, carotenoids, dietary fibre and phenolic acids.

These health-promoting foods or components may be categorised into two important classes: nutraceuticals and functional foods. A wide variety of cereals, fruits and vegetables, and other food supply plenty of bioactive compounds like phytochemicals (flavonoids, phenolic acids, alkaloids, and carotenoids), vitamins (vitamin C, folate, and provitamin A), minerals (potassium, calcium, and magnesium), and fibres. Therefore, in order to receive the greatest health benefits, one should consume a wide variety of plant-based foods daily.

Bioactive compounds in functional foods and disease prevention
These compounds purportedly confer diverse health benefits and are believed to interfere with the pathogenesis of several diseases.

1.    Bioactive Proteins and Peptides
These bioactive peptides may exert a wide variety of beneficial biological functions in the body such as regulating serum cholesterol and hypocholesterolemic effect through binding of bile acids. Eliminating bile acids may increase cholesterol metabolism and help reduce cholesterol levels in the blood. Other bioactive proteins and peptides may provide positive influence on calcium absorption and dental health by inhibiting plaque-forming bacteria and tooth enamel demineralisation.

2.    PUFAs
PUFAs, the FAs with more than a single carbon–carbon double bond reported several beneficial effects include anti-inflammatory, immunomodulatory, cardioprotective, and antiatherosclerotic effects. Well-known examples of PUFAs are the long-chain ?-3 FAs, which are considered to be essential because they cannot be effectively synthesised by the body due to the low activity of the rate-limiting enzyme ?6-desaturase.

PUFAs also serve as precursors for prostaglandins, leukotrienes, and eicosanoids such as resolvins and protectins, which are known for their anti-inflammatory and neuroprotective activities. Other beneficial effects of long-chain PUFAs include lowering plasma triglyceride concentration, improving plasma lipoprotein profile, supporting fetal brain and eye development, cognitive health and maintenance, better performance or preservation of cognitive function in ageing persons, improved cardiovascular health, and reduced risk of metabolic-syndrome-related conditions such as obesity and insulin resistance syndrome. Fish is the rich source of PUFAs but ?-3 PUFA. Other known sources of PUFAs are avocados, peanut butter, many nuts and seeds (e.g., flaxseeds, chia seeds, walnuts, pumpkin seeds), and the oils of canola (rapeseed), corn, olive, flaxseed, sesame, soybean, and sunflower.

3.    Phytochemicals and Phytoestrogens
Phytochemicals are a group of plant secondary metabolites valued for their health benefits (e.g., as radical scavengers and quenchers of singlet oxygen). They have been shown to safely suppress pro-inflammatory pathways, reduce low-density lipoprotein (LDL) cholesterol, protect against damage caused by LDL cholesterol, and reduce the risk of atherosclerosis or plaque build-up in arteries that can lead to heart attack or stroke and contribute to CHD. Their antimicrobial properties may prevent the reversible and epigenetic changes in the body’s cells often linked to diseases.

Phytochemicals include flavonoids (flavanols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and proanthocyanidins), carotenoids, as well as other polyphenols. Flavanols, flavones, and flavanones are the main flavonoids that occur in citrus. Several studies have suggested that the high concentrations of flavanols found in cocoa-rich products and dark chocolates increase the formation of endothelial nitric oxide, which promotes vasodilation and therefore may reduce blood pressure and risk of CVD.

Phytoestrogens are plant-derived phenolic compounds that are structurally and/or functionally similar to mammalian estrogens. They include isoflavones, coumestans, and lignans, which are most notably found in soybeans, clover and alfalfa sprouts, and oilseeds (such as flaxseed), respectively. Soybean is uniquely rich in the isoflavones genistein (4',5,7 trihydroxyisoflavone) and daidzein (4',7-trihydroxyisoflavone), and, to a small extent, glycitein.

Flaxseeds contain the lignin secoisolariciresinol diglucoside, matairesinol, pinoresinol, and lariciresinol. Phytoestrogens may play an important role in obesity and diabetes by improving glucose control and insulin resistance via pancreatic insulin secretion mechanisms. Phytoestrogens are also of particular importance in women’s health, and their role includes reducing the risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms, among others.

4.    Fibre
Fibre, also known as “non-starch polysaccharide,” is derived from the cell wall of plants such as cellulose, hemicellulose, and pectin and is metabolised differently from other forms of carbohydrates, generally resistant to digestion and absorption. Fibre is further classified as soluble (food gums/hydrocolloids and pectin) and insoluble (cellulose and hemicellulose). The soluble components of the dietary fibre are degraded by microflora, resulting in a substantial stimulation of microbial growth and an increased faecal bulk.

Soluble fibre also affects glucose and lipid absorption into the bloodstream by lowering serum cholesterol. Insoluble fibre is resistant to breakdown by the microflora and has been identified for their role in laxation and bowel habit by retaining water within the cellular structure, intestinal transit time, production of short-chain FAs, and prebiotic effect. Their indigestible and fermentable nature mainly defines their nutraceutical and functional properties.

Apart from the physiological properties of this fibrous material, fibres are suitable fermentable substrates adjuncts for probiotics and encapsulation shells. The cholesterol-lowering effect of fibre may be related to ß-glucan mediation in increasing bile acid secretion. Fibre is ubiquitous in grains, legumes, and vegetables. Wheat bran and whole grains, as well as the skins of many fruits and vegetables, and seeds, are rich sources of insoluble fibre. Soluble fibre is found in oats, legumes (peas, kidney beans, and lentils), some seeds, brown rice, barley, oats, fruits (e.g., apples), some green vegetables (e.g., broccoli), and potatoes. Oats and barley have the highest ß-glucan content among cereals.

5.    Prebiotics and Probiotics
The FAO/WHO define probiotics as live microorganisms that when administered in adequate amounts confer a health benefit on the host while a prebiotic has been defined as a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth or activity of one or a limited number of bacteria in the colon and thus improves host health.

The importance of probiotics and prebiotics as nutraceuticals and functional foods stems from their ability to improve intestinal microflora, and to reduce and inhibit the growth pathogenic strains such as E. coli and Salmonella, allergic disorders, diarrhoea, and inflammatory bowel disease.

 For dietary products, bacterial count of at least 106 CFU ml-1 is commonly accepted. Bacterial strains from the genera Lactobacillus, Bifidobacterium, and Bacillus are three known sources of probiotics.

 Known examples of prebiotics include non-digestible oligosaccharides such as inulin (fruits and vegetables), fructo-oligosaccharides, galacto-oligosaccharides, lactulose, and resistant starch. They may also play an important role in colonic health and other GI illnesses by stimulating the beneficial activity and proliferation of specific members of the intestinal microflora, prevent colonisation by potential pathogens, produce beneficial short-chain FAs (such as acetic acid, propionic acid, and butyric acid, which are used by the host organism as an energy source), and stimulate calcium absorption from food. Prebiotics and probiotics in foods and beverages and as supplements may enhance health independently, or in combination (also referred to as synbiotics).


(The authors are Ph D scholar, HoD, and ADP at College of Food Technology, VNMKV, Parbhani)
 
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