Thursday, May 24, 2018


Salty food diminishes thirst, ups hunger due to need for higher energy
Thursday, 20 April, 2017, 08 : 00 AM [IST]
It is a myth that eating salty foods makes you thirstier. In a study carried out during a simulated mission to Mars, an international group of scientists has found exactly the opposite to be true. Cosmonauts, who ate more salt retained more water, weren’t as thirsty, and needed more energy.

No long-term studies were carried out to determine the relationship between the amount of salt in a person’s diet and his drinking habits. Scientists have known that increasing a person’s salt intake stimulates the production of more urine. It has simply been assumed that the extra fluid comes from drinking.

But researchers from the German Aerospace Center (DLR), the Max Delbrück Center for Molecular Medicine (MDC), Vanderbilt University and colleagues around the world disagree.

Recently they took advantage of a simulated mission to Mars to put the old adage to the test. Their conclusions appear in two papers in the current issue of the Journal of Clinical Investigation.

Simulated space trip provides experimental conditions
What does salt have to do with Mars? Nothing, really, except that on a long space voyage, conserving every drop of water might be crucial. A connection between salt intake and drinking could affect your calculations – you wouldn’t want an interplanetary traveller to die because he liked an occasional pinch of salt on his food.

The real interest in the simulation, however, was that it provided an environment in which every aspect of a person’s nutrition, water consumption and salt intake could be controlled and measured.

The studies were carried out by Natalia Rakova of the Charité and MDC and her colleagues. The subjects were two groups of ten male volunteers sealed into a mock spaceship for two simulated flights to Mars.

The first group was examined for 105 days, and the second over 205 days. They had identical diets except that over periods lasting several weeks, they were given three different levels of salt in their food.

Mock spacemen drink less on salty diet
The results brought some surprises over the long-term. In the short-tern, the results confirmed the bartender’s wisdom - salted peanuts will increase your beverage sales.

Eating more salt also leads to a higher salt content in urine; there is no surprise there. Nor was there any surprise in a correlation between the amounts of salt and the overall quantity of urine.

But the increase was not due to more drinking. In fact, a salty diet caused the subjects to drink less. The reason was that salt was triggering a mechanism to conserve water in the kidneys.

Before the study, the prevailing hypothesis had been that the charged sodium and chloride ions in salt grabbed onto water molecules and dragged them into the urine. The new results showed something different - salt stayed in the urine, while water moved back into the kidney and body.

This was completely puzzling to Jens Titze of the University of Erlangen-Nürnberg and Vanderbilt University Medical Centre and his colleagues. “What alternative driving force could make water move back?” he asked.

Experiments in mice hinted that urea might be involved. This substance is formed in muscles and the liver as a way of shedding nitrogen.

In mice, urea was accumulating in the kidney, where it counteracts the water-drawing force of sodium and chloride. But synthesising urea takes a lot of energy, which explains why mice on a high-salt diet were eating more.

Higher salt didn’t increase their thirst, but it did make them hungrier. Also the human cosmonauts receiving a salty diet complained about being hungry.

Urea not just waste product
The project revises scientists’ view of the function of urea in our bodies. “It’s not solely a waste product, as has been assumed,” said Friedrich C Luft of the Charité and MDC.

“Instead, it turns out to be a very important osmolyte – a compound that binds to water and helps transport it. Its function is to keep water in when our bodies get rid of salt. Nature has apparently found a way to conserve water that would otherwise be carried away into the urine by salt,” he added.

The new findings change the way scientists have thought about the process by which the body achieves water homeostasis – maintaining a proper amount and balance. That must happen whether a body is being sent to Mars or not.

“We now have to see this process as a concerted activity of the liver, muscle and kidney,” Titze said.

“While we didn’t directly address blood pressure and other aspects of the cardiovascular system, it’s also clear that their functions are tightly connected to water homeostasis and energy metabolism,” he added.

This project is primarily a product of DLR research under space conditions. At the MDC are Natalia Rakova, Dominik N Müller and Friedrich C Luft. Jens Titze of University Medicine Erlangen-Nürnberg and Vanderbilt University is the senior author, where Friedrich C Luft is also an affiliated faculty member.

Natalia Rakova,1,2 Kento Kitada,3 Kathrin Lerchl,2 Anke Dahlmann,2 Anna Birukov,2 Steffen Daub,3,4 Christoph Kopp,2 Tetyana Pedchenko,3 Yahua Zhang,3 Luis Beck,5 Bernd Johannes,5 Adriana Marton,3 Dominik N Müller,1 Manfred Rauh,6 Friedrich C Luft,1,3 and Jens Titze2,3 (2017): “Increased salt consumption induces body water conservation and decreases fluid intake.” The Journal of Clinical Investigation.

1Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. 2University Clinic Erlangen, Erlangen, Germany. 3Vanderbilt University Medical Center, Nashville, Tennessee, USA. 4University Medical Center Mainz, Mainz, Germany. 5German Aerospace Center, Cologne, Germany. 6University Clinic Erlangen, Erlangen, Germany.

Kento Kitada,1 Steffen Daub,1,2 Yahua Zhang,1 Janet D Klein,3,4 Daisuke Nakano,5 Tetyana Pedchenko,1 Louise Lantier,6 Lauren M LaRocque,3 Adriana Marton,1 Patrick Neubert,7 Agnes Schröder,7 Natalia Rakova,8 Jonathan Jantsch,9?Anna E Dikalova,1 Sergey I Dikalov,1 David G Harrison,1 Dominik N Müller,8 Akira Nishiyama,5 Manfred Rauh,10 Raymond C Harris,11 Friedrich C Luft,1,8 David H Wassermann,6 Jeff M Sands,3,4 and Jens Titze1,7 (2017): “High salt intake reprioritises osmolyte and energy metabolism for body fluid conservation.” The Journal of Clinical Investigation.

1Vanderbilt University Medical Center, Nashville, Tennessee, USA. 2University Medical Center Mainz, Mainz, Germany. 3,4Emory University, Atlanta, Georgia, USA. 5Kagawa University, Kagawa, Japan. 6Vanderbilt University, Nashville, Tennessee, USA. 7University Clinic Erlangen, Erlangen, Germany. 8Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. 9University Clinic Regensburg and University Regensburg, Regensburg, Germany. 10University Clinic Erlangen, Erlangen, Germany. 11Vanderbilt University Medical Center, Nashville, Tennessee, USA.
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